Protein-based chelators for targeted radionuclide therapy. Short-lived, radioactive lanthanides are attractive radioisotopes for targeted radionuclide therapy, which is a rapidly growing class of cancer treatment. To deliver such isotopes to the target cancer cells, they must be appended, i.e. chelated, to carriers that target antigens overexpressed on the target cancer cell’s surface. For the production of such radiopharmaceuticals, it is highly desirable to use chelating molecules that can capture large radioisotopes with high specificity and stability under mild temperature and pH conditions, leaving the carrier protein molecule and target binding capacity intact. Here, we aim to improve the development of radiopharmaceuticlas via implementing and benchmarking protein-based alternatives to the currently used synthetic chemical chelators. As additional innovation, these protein-based alternatives will be directly fused to proteinous carriers (e.g. peptides or nanobodies), produced recombinantly and benchmarked.Both innovative approaches provide unique possibilities for targeted radionuclide therapy.
More info at: https://www.sckcen.be/en/PhD_MNA_MIC_Protein-based_chelators. As from March 5th, 2024, you can apply to this PhD topic via this link. Before applying, please consult the guidelines for application.
Biosynthetic toolboxes for the extraction of radionuclides. Short-lived radioactive lanthanides are attractive radioisotopes for targeted radionuclide therapy, which is a rapidly growing class of cancer treatment. The development of such radiopharmaceuticals evidently relies on the production of these radioisotopes and generates particular waste streams. Although both are routine and established practices, researchers are exploring novel approaches as an alternative to extract or recover radionuclides in order to circumvent current drawbacks. This involves developing and using specially engineered microorganisms that are modified to bind to the desired elements. By selecting or engineering the right bacterial strains, highly specific and efficient extraction systems can be obtained. In this project, different biosynthetic toolboxes will be developed and compared. A synthetic approach will be used in order to engineer the desirable features, i.e. radionuclide-binding, on the surface of different microorganisms. The developed tools will be assessed side-by-side and their potential to quantitatively and selectively recover radionuclides will be evaluated. This innovative approach will allow optimizing the product life cycle and will contribute to the successful implementation of targeted radionuclide therapy. In addition, the use of microorganisms in element extraction/recovery is part of a broader trend toward sustainable and environmentally responsible sourcing of critical materials.
More info at: https://www.sckcen.be/en/PhD_MNA_MIC_biosynthetic_toolboxes. As from March 5th, 2024, you can apply to this PhD topic via this link. Before applying, please consult the guidelines for application.